Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors

Persistent DNA double strand breaks (DSBs) may determine the anti-tumor effects of ionizing radiation (IR) by inducing apoptosis, necrosis, mitotic catastrophe or permanent growth arrest. Ionizing radiation (IR) induces rapid modification of megabase chromatin domains surrounding double strand break...

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Detalhes bibliográficos
Main Authors: Efimova, Elena V., Mauceri, Helena J., Golden, Daniel W., Labay, Edwardine, Bindokas, Vytautas P., Darga, Thomas E., Chakraborty, Chaitali, Andrade, Juan Camilo Barreto, Crawley, Clayton, Sutton, Harold G., Kron, Stephen J., Weichselbaum, Ralph R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912962/
https://ncbi.nlm.nih.gov/pubmed/20610628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4224
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