Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors

Persistent DNA double strand breaks (DSBs) may determine the anti-tumor effects of ionizing radiation (IR) by inducing apoptosis, necrosis, mitotic catastrophe or permanent growth arrest. Ionizing radiation (IR) induces rapid modification of megabase chromatin domains surrounding double strand break...

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Detaylı Bibliyografya
Asıl Yazarlar: Efimova, Elena V., Mauceri, Helena J., Golden, Daniel W., Labay, Edwardine, Bindokas, Vytautas P., Darga, Thomas E., Chakraborty, Chaitali, Andrade, Juan Camilo Barreto, Crawley, Clayton, Sutton, Harold G., Kron, Stephen J., Weichselbaum, Ralph R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912962/
https://ncbi.nlm.nih.gov/pubmed/20610628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4224
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