Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors

Persistent DNA double strand breaks (DSBs) may determine the anti-tumor effects of ionizing radiation (IR) by inducing apoptosis, necrosis, mitotic catastrophe or permanent growth arrest. Ionizing radiation (IR) induces rapid modification of megabase chromatin domains surrounding double strand break...

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Autors principals: Efimova, Elena V., Mauceri, Helena J., Golden, Daniel W., Labay, Edwardine, Bindokas, Vytautas P., Darga, Thomas E., Chakraborty, Chaitali, Andrade, Juan Camilo Barreto, Crawley, Clayton, Sutton, Harold G., Kron, Stephen J., Weichselbaum, Ralph R.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912962/
https://ncbi.nlm.nih.gov/pubmed/20610628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4224
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