Disruption of Peripheral Circadian Timekeeping in a Mouse Model of Huntington's Disease and Its Restoration by Temporally Scheduled Feeding

Behavioral circadian rhythms disintegrate progressively in the R6/2 mouse model of Huntington's disease (HD), recapitulating the sleep–wake disturbance seen in HD patients. Here we show that disturbances in circadian pacemaking are not restricted to the brain, but also encompass peripheral meta...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Maywood, Elizabeth S., Fraenkel, Eloise, McAllister, Catherine J., Wood, Nigel, Reddy, Akhilesh B., Hastings, Michael H., Morton, A. Jennifer
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633357/
https://ncbi.nlm.nih.gov/pubmed/20668203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1694-10.2010
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