Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM–ULM interaction

Stable recognition of the intron branchpoint (BP) by the U2 snRNP to form the pre-spliceosome is the first ATP-dependent step of splicing. Genetic and biochemical data from yeast indicate that Cus2 aids U2 snRNA folding into the stem IIa conformation prior to pre-spliceosome formation. Cus2 must the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RNA
Prif Awduron: Talkish, Jason, Igel, Haller, Hunter, Oarteze, Horner, Steven W., Jeffery, Nazish N., Leach, Justin R., Jenkins, Jermaine L., Kielkopf, Clara L., Ares, Manuel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633205/
https://ncbi.nlm.nih.gov/pubmed/31110137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.070649.119
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