Involvement of a Subpopulation of Neuronal M(4) Muscarinic Acetylcholine Receptors in the Antipsychotic-like Effects of the M(1)/M(4) Preferring Muscarinic Receptor Agonist Xanomeline

Disturbances in central dopaminergic neurotransmission are believed to be centrally involved in the pathogenesis of schizophrenia. Central dopaminergic and cholinergic systems interact and the cholinergic muscarinic agonist xanomeline has shown antipsychotic effects in clinical studies. Preclinical...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Dencker, Ditte, Wörtwein, Gitta, Weikop, Pia, Jeon, Jongrye, Thomsen, Morgane, Sager, Thomas N., Mørk, Arne, Woldbye, David P. D., Wess, Jürgen, Fink-Jensen, Anders
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2011
Sujets:
Brief Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632952/
https://ncbi.nlm.nih.gov/pubmed/21508215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0370-11.2011
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