Involvement of a Subpopulation of Neuronal M(4) Muscarinic Acetylcholine Receptors in the Antipsychotic-like Effects of the M(1)/M(4) Preferring Muscarinic Receptor Agonist Xanomeline

Disturbances in central dopaminergic neurotransmission are believed to be centrally involved in the pathogenesis of schizophrenia. Central dopaminergic and cholinergic systems interact and the cholinergic muscarinic agonist xanomeline has shown antipsychotic effects in clinical studies. Preclinical...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Dencker, Ditte, Wörtwein, Gitta, Weikop, Pia, Jeon, Jongrye, Thomsen, Morgane, Sager, Thomas N., Mørk, Arne, Woldbye, David P. D., Wess, Jürgen, Fink-Jensen, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2011
Schlagworte:
Brief Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632952/
https://ncbi.nlm.nih.gov/pubmed/21508215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0370-11.2011
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