Increased Cocaine Self-Administration in M(4) Muscarinic Acetylcholine Receptor Knockout Mice

RATIONALE: The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic muscarinic M(4) receptor subtype plays an important role in regulation of dopaminergic neurotransmission. OBJECTIVES: Here we investigate...

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Main Authors: Schmidt, Lene S., Thomsen, Morgane, Weikop, Pia, Dencker, Ditte, Wess, Jürgen, Woldbye, David P.D., Wortwein, Gitta, Fink-Jensen, Anders
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899540/
https://ncbi.nlm.nih.gov/pubmed/21373792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2225-4
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