Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

IMPORTANCE: A National Institute on Aging–Alzheimer’s Association (NIA-AA) workgroup recently published a research framework in which Alzheimer disease is defined by neuropathologic or biomarker evidence of β-amyloid plaques and tau tangles and not by clinical symptoms. OBJECTIVES: To estimate the s...

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Publicado en:JAMA Neurol
Autores principales: Jack, Clifford R., Therneau, Terry M., Weigand, Stephen D., Wiste, Heather J., Knopman, David S., Vemuri, Prashanthi, Lowe, Val J., Mielke, Michelle M., Roberts, Rosebud O., Machulda, Mary M., Graff-Radford, Jonathan, Jones, David T., Schwarz, Christopher G., Gunter, Jeffrey L., Senjem, Matthew L., Rocca, Walter A., Petersen, Ronald C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Medical Association 2019
Materias:
Original Investigation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632154/
https://ncbi.nlm.nih.gov/pubmed/31305929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1971
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