Defining imaging biomarker cut-points for brain aging and Alzheimer’s disease

INTRODUCTION: Our goal was to develop cut-points for amyloid PET, tau PET, FDG PET, and MRI cortical thickness. METHODS: We examined five methods for determining cut-points. RESULTS: The reliable worsening method produced a cut-point only for amyloid PET. The specificity, sensitivity, and accuracy o...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement
Main Authors: Jack, Clifford R., Wiste, Heather J., Weigand, Stephen D., Therneau, Terry M., Lowe, Val J., Knopman, David S., Gunter, Jeffrey L., Senjem, Matthew L., Jones, David T., Kantarci, Kejal, Machulda, Mary M., Mielke, Michelle M., Roberts, Rosebud O., Vemuri, Prashanthi, Reyes, Denise A., Petersen, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344738/
https://ncbi.nlm.nih.gov/pubmed/27697430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.08.005
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