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Stochastic modeling of aging cells reveals how damage accumulation, repair, and cell-division asymmetry affect clonal senescence and population fitness

BACKGROUND: Asymmetry during cellular division, both in the uneven partitioning of damaged cellular components and of cell volume, is a cell biological phenomenon experienced by many unicellular organisms. Previous work based on a deterministic model claimed that such asymmetry in the partitioning o...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Song, Ruijie, Acar, Murat
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631810/
https://ncbi.nlm.nih.gov/pubmed/31307385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-2921-3
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