To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage

Excessive DNA damage can induce an irreversible cell cycle arrest, called senescence, which is generally perceived as an important tumour-suppressor mechanism. However, it is unclear how cells decide whether to senesce or not after DNA damage. By combining experimental data with a parameterized math...

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Detalles Bibliográficos
Publicado en:Aging (Albany NY)
Main Authors: Kollarovic, Gabriel, Studencka, Maja, Ivanova, Lyubomira, Lauenstein, Claudia, Heinze, Kristina, Lapytsko, Anastasiya, Talemi, Soheil Rastgou, Figueiredo, Ana Sofia, Schaber, Jörg
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761720/
https://ncbi.nlm.nih.gov/pubmed/26830321
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