To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage

Excessive DNA damage can induce an irreversible cell cycle arrest, called senescence, which is generally perceived as an important tumour-suppressor mechanism. However, it is unclear how cells decide whether to senesce or not after DNA damage. By combining experimental data with a parameterized math...

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Spremljeno u:
Bibliografski detalji
Izdano u:Aging (Albany NY)
Glavni autori: Kollarovic, Gabriel, Studencka, Maja, Ivanova, Lyubomira, Lauenstein, Claudia, Heinze, Kristina, Lapytsko, Anastasiya, Talemi, Soheil Rastgou, Figueiredo, Ana Sofia, Schaber, Jörg
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761720/
https://ncbi.nlm.nih.gov/pubmed/26830321
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