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Senoptosis: non-lethal DNA cleavage as a route to deep senescence

DNA-damage-induced apoptosis and cellular senescence are perceived as two distinct cell fates. We found that after ionizing radiation (IR)-induced DNA damage the majority (up to 70 %) of senescent human diploid fibroblasts (HDFs) were subjected to controlled cleavage of DNA, resulting in the establi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Studencka, Maja, Schaber, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458157/
https://ncbi.nlm.nih.gov/pubmed/28427150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15693
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