Multi-Color Single-Molecule Imaging Uncovers Extensive Heterogeneity in mRNA Decoding

mRNA translation is a key step in decoding genetic information. Genetic decoding is surprisingly heterogeneous because multiple distinct polypeptides can be synthesized from a single mRNA sequence. To study translational heterogeneity, we developed the MoonTag, a fluorescence labeling system to visu...

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Udgivet i:Cell
Main Authors: Boersma, Sanne, Khuperkar, Deepak, Verhagen, Bram M.P., Sonneveld, Stijn, Grimm, Jonathan B., Lavis, Luke D., Tanenbaum, Marvin E.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630898/
https://ncbi.nlm.nih.gov/pubmed/31178119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.05.001
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