Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration

The goal of this study was to investigate the potential for a cannabidiol-rich cannabis extract (CRCE) to interact with the most common over-the-counter drug and the major known cause of drug-induced liver injury–acetaminophen (APAP)–in aged female CD-1 mice. Gavaging mice with 116 mg/kg of cannabid...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Ewing, Laura E., McGill, Mitchell R., Yee, Eric U., Quick, Charles M., Skinner, Charles M., Kennon-McGill, Stefanie, Clemens, Melissa, Vazquez, Joel H., McCullough, Sandra S., Williams, D. Keith, Kutanzi, Kristy R., Walker, Larry A., ElSohly, Mahmoud A., James, Laura P., Gurley, Bill J., Koturbash, Igor
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630875/
https://ncbi.nlm.nih.gov/pubmed/31212965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24122256
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