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Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Cell-based screening has become the major compound interrogation strategy in Chagas disease drug discovery. Several different cell lines have been deployed as host cells in screening assays. However, host cell characteristics and host-parasite interactions may play an important role when assessing a...

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Dades bibliogràfiques
Publicat a:Trop Med Infect Dis
Autors principals: Franco, Caio Haddad, Alcântara, Laura Maria, Chatelain, Eric, Freitas-Junior, Lucio, Moraes, Carolina Borsoi
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630705/
https://ncbi.nlm.nih.gov/pubmed/31108888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/tropicalmed4020082
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