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Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection

Cell-based screening has become the major compound interrogation strategy in Chagas disease drug discovery. Several different cell lines have been deployed as host cells in screening assays. However, host cell characteristics and host-parasite interactions may play an important role when assessing a...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Trop Med Infect Dis
Main Authors: Franco, Caio Haddad, Alcântara, Laura Maria, Chatelain, Eric, Freitas-Junior, Lucio, Moraes, Carolina Borsoi
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630705/
https://ncbi.nlm.nih.gov/pubmed/31108888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/tropicalmed4020082
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