Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington’s Disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the HTT gene. HD usually manifests in mid-life with loss of GABAergic projection neurons from the striatum accompanied by progressive atrophy of the putamen followed by other brain regions, but li...

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Udgivet i:Metabolites
Main Authors: Patassini, Stefano, Begley, Paul, Xu, Jingshu, Church, Stephanie J., Kureishy, Nina, Reid, Suzanne J., Waldvogel, Henry J., Faull, Richard L. M., Snell, Russell G., Unwin, Richard D., Cooper, Garth J. S.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630497/
https://ncbi.nlm.nih.gov/pubmed/31212603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo9060113
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