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Acute and chronic hypoxia differentially predispose lungs for metastases

Oscillations in oxygen levels affect malignant cell growth, survival, and metastasis, but also somatic cell behaviour. In this work, we studied the effect of the differential expression of the two primary hypoxia inducible transcription factor isoforms, HIF-1α and HIF-2α, and pulmonary hypoxia to in...

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Pubblicato in:Sci Rep
Autori principali: Reiterer, Moritz, Colaço, Renato, Emrouznejad, Pardis, Jensen, Anders, Rundqvist, Helene, Johnson, Randall S., Branco, Cristina
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629695/
https://ncbi.nlm.nih.gov/pubmed/31308473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46763-y
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