Acute LPS sensitization and continuous infusion exacerbates hypoxic brain injury in a piglet model of neonatal encephalopathy

Co-existing infection/inflammation and birth asphyxia potentiate the risk of developing neonatal encephalopathy (NE) and adverse outcome. In a newborn piglet model we assessed the effect of E. coli lipopolysaccharide (LPS) infusion started 4 h prior to and continued for 48 h after hypoxia on brain c...

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Vydáno v:Sci Rep
Hlavní autoři: Martinello, Kathryn A., Meehan, Christopher, Avdic-Belltheus, Adnan, Lingam, Ingran, Ragab, Sara, Hristova, Mariya, Tann, Cally J., Peebles, Donald, Hagberg, Henrik, Wolfs, Tim G. A. M., Klein, Nigel, Tachtsidis, Ilias, Golay, Xavier, Kramer, Boris W., Fleiss, Bobbi, Gressens, Pierre, Robertson, Nicola J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629658/
https://ncbi.nlm.nih.gov/pubmed/31308390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46488-y
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