Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia–Ischemia With and Without Inflammation-Sensitization

Despite therapeutic hypothermia, survivors of neonatal encephalopathy have high rates of adverse outcome. Early surrogate outcome measures are needed to speed up the translation of neuroprotection trials. Thalamic lactate (Lac)/N-acetylaspartate (NAA) peak area ratio acquired with proton ((1)H) magn...

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Bibliographic Details
Published in:Front Neurol
Main Authors: Pang, Raymand, Martinello, Kathryn A., Meehan, Christopher, Avdic-Belltheus, Adnan, Lingam, Ingran, Sokolska, Magda, Mutshiya, Tatenda, Bainbridge, Alan, Golay, Xavier, Robertson, Nicola J.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Neurology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7500093/
https://ncbi.nlm.nih.gov/pubmed/33013626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2020.00883
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