Non-invasive in vivo quantification of AAV9-mediated expression of the sodium/iodide Symporter (NIS) under hind-limb ischemia and neuraminidase desialylation in skeletal muscle using SPECT/CT

BACKGROUND: We propose microSPECT/CT imaging of the human sodium/iodide symporter (hNIS) to noninvasively quantify AAV9-mediated gene expression in a murine model of peripheral artery disease (PAD). METHODS: AAV9-hNIS (2 * 10(11) vpg) was injected into non-ischemic or ischemic gastrocnemius (GA) mus...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Circ Cardiovasc Imaging
Main Authors: Boutagy, Nabil E., Ravera, Silvia, Papademetris, Xenophon, Onofrey, John A., Zhuang, Zhen W., Wu, Jing, Feher, Attila, Stacy, Mitchel R., French, Brent A., Annex, Brian H., Carrasco, Nancy, Sinusas, Albert J.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629470/
https://ncbi.nlm.nih.gov/pubmed/31296047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCIMAGING.119.009063
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares