Non-invasive in vivo quantification of AAV9-mediated expression of the sodium/iodide Symporter (NIS) under hind-limb ischemia and neuraminidase desialylation in skeletal muscle using SPECT/CT

BACKGROUND: We propose microSPECT/CT imaging of the human sodium/iodide symporter (hNIS) to noninvasively quantify AAV9-mediated gene expression in a murine model of peripheral artery disease (PAD). METHODS: AAV9-hNIS (2 * 10(11) vpg) was injected into non-ischemic or ischemic gastrocnemius (GA) mus...

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Bibliographic Details
Published in:Circ Cardiovasc Imaging
Main Authors: Boutagy, Nabil E., Ravera, Silvia, Papademetris, Xenophon, Onofrey, John A., Zhuang, Zhen W., Wu, Jing, Feher, Attila, Stacy, Mitchel R., French, Brent A., Annex, Brian H., Carrasco, Nancy, Sinusas, Albert J.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629470/
https://ncbi.nlm.nih.gov/pubmed/31296047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCIMAGING.119.009063
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