Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice

Parkinson’s disease (PD) is primarily a nonfamilial, age-related disorder caused by α-synuclein accumulation and the progressive loss of dopamine neurons in the substantia nigra pars compacta (SNc). GPCR-cAMP signaling has been linked to a reduction in human PD incidence and α-synuclein expression....

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Publicat a:JCI Insight
Autors principals: Luo, Zili, Ahlers-Dannen, Katelin E., Spicer, Mackenzie M., Yang, Jianqi, Alberico, Stephanie, Stevens, Hanna E., Narayanan, Nandakumar S., Fisher, Rory A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629243/
https://ncbi.nlm.nih.gov/pubmed/31120439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126769
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