A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity

Ubiquitin-conjugating enzyme E2O (UBE2O) is expressed preferentially in metabolic tissues, but its role in regulating energy homeostasis has yet to be defined. Here we find that UBE2O is markedly upregulated in obese subjects with type 2 diabetes and show that whole-body disruption of Ube2o in mouse...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:JCI Insight
Hoofdauteurs: Vila, Isabelle K., Park, Mi Kyung, Setijono, Stephanie Rebecca, Yao, Yixin, Kim, Hyejin, Badin, Pierre-Marie, Choi, Sekyu, Narkar, Vihang, Choi, Sung-Woo, Chung, Jongkyeong, Moro, Cedric, Song, Su Jung, Song, Min Sup
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2019
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629239/
https://ncbi.nlm.nih.gov/pubmed/31292296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128269
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items