A UBE2O-AMPKα2 Axis That Promotes Tumor Initiation and Progression Offers Opportunities for Therapy

UBE2O is localized in the 17q25 locus, which is known to be amplified in human cancers, but its role in tumorigenesis remains undefined. Here we show that Ube2o deletion in MMTV-PyVT or TRAMP mice profoundly impairs tumor initiation, growth and metastasis, while switching off the metabolic reprogram...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Vila, Isabelle K., Yao, Yixin, Kim, Goeun, Xia, Weiya, Kim, Hyejin, Kim, Sun-Joong, Park, Mi Kyung, Hwang, James P., Billalabeitia, Enrique González, Hung, Mien-Chie, Song, Su Jung, Song, Min Sup
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5463996/
https://ncbi.nlm.nih.gov/pubmed/28162974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.01.003
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