A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity

Ubiquitin-conjugating enzyme E2O (UBE2O) is expressed preferentially in metabolic tissues, but its role in regulating energy homeostasis has yet to be defined. Here we find that UBE2O is markedly upregulated in obese subjects with type 2 diabetes and show that whole-body disruption of Ube2o in mouse...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Vila, Isabelle K., Park, Mi Kyung, Setijono, Stephanie Rebecca, Yao, Yixin, Kim, Hyejin, Badin, Pierre-Marie, Choi, Sekyu, Narkar, Vihang, Choi, Sung-Woo, Chung, Jongkyeong, Moro, Cedric, Song, Su Jung, Song, Min Sup
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629239/
https://ncbi.nlm.nih.gov/pubmed/31292296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128269
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