Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

Chimeric antigen receptor (CAR) T cell therapies have achieved promising outcomes in several cancers; however, more challenging oncology indications may necessitate advanced antigen receptor designs and functions. Here we describe a bipartite receptor system composed of separate antigen-targeting an...

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Vydáno v:JCI Insight
Hlavní autoři: Leung, Wai-Hang, Gay, Joel, Martin, Unja, Garrett, Tracy E., Horton, Holly M., Certo, Michael T., Blazar, Bruce R., Morgan, Richard A., Gregory, Philip D., Jarjour, Jordan, Astrakhan, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629089/
https://ncbi.nlm.nih.gov/pubmed/31039141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124430
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