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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
CRISPR-Cas12a (Cpf1) proteins are RNA-guided DNA targeting enzymes that bind and cut DNA as components of bacterial adaptive immune systems. Like CRISPR-Cas9, Cas12a can be used as a powerful genome editing tool based on its ability to induce genetic changes in cells at sites of double-stranded DNA...
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| I publikationen: | Science |
|---|---|
| Huvudupphovsmän: | , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2018
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6628903/ https://ncbi.nlm.nih.gov/pubmed/29449511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar6245 |
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