Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade

We have recently defined a novel population of PD-1 (programmed cell death 1)+ TCF1 (T cell factor 1)+ virus-specific CD8 T cells that function as resource cells during chronic LCMV infection and provide the proliferative burst seen after PD-1 blockade. Such CD8 T cells have been found in other chro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Jadhav, Rohit R., Im, Se Jin, Hu, Bin, Hashimoto, Masao, Li, Peng, Lin, Jian-Xin, Leonard, Warren J., Greenleaf, William J., Ahmed, Rafi, Goronzy, Jorg J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2019
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628832/
https://ncbi.nlm.nih.gov/pubmed/31227606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903520116
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