The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model

BACKGROUND: Blood–brain barrier dysfunction is associated with many late-stage neurodegenerative diseases. An emerging question is whether the mutations associated with neurodegenerative diseases can independently lead to blood–brain barrier (BBB) dysfunction. Studies from patient-derived induced pl...

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Bibliographic Details
Published in:Fluids Barriers CNS
Main Authors: Katt, Moriah E., Mayo, Lakyn N., Ellis, Shannon E., Mahairaki, Vasiliki, Rothstein, Jeffrey D., Cheng, Linzhao, Searson, Peter C.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628493/
https://ncbi.nlm.nih.gov/pubmed/31303172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-019-0139-4
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