Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor

Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamate...

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Veröffentlicht in:Biomolecules
Hauptverfasser: Fukuyama, Kouji, Kato, Ryo, Murata, Masahiko, Shiroyama, Takashi, Okada, Motohiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628267/
https://ncbi.nlm.nih.gov/pubmed/31213006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9060234
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