Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc(−)

Deficiencies in N‐methyl‐d‐aspartate (NMDA)/glutamate receptor (NMDAR) signaling have been considered central to the cognitive impairments of schizophrenia; however, an NMDAR antagonist memantine (MEM) improves cognitive impairments of Alzheimer's disease and schizophrenia. These mechanisms of...

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Bibliografiske detaljer
Udgivet i:Pharmacol Res Perspect
Main Authors: Okada, Motohiro, Fukuyama, Kouji, Kawano, Yasuhiro, Shiroyama, Takashi, Ueda, Yuto
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323135/
https://ncbi.nlm.nih.gov/pubmed/30784207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.457
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