The activin receptor is stimulated in the skeleton, vasculature, heart and kidney during chronic kidney disease.

We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome, using the ActRIIA ligand trap RAP-011 initiated in 75 day old Alport mice. At 200 days of age there was severe CKD and associated Mineral and Bon...

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Veröffentlicht in:Kidney Int
Hauptverfasser: Williams, Matthew J., Sugatani, Toshifumi, Agapova, Olga A., Fang, Yifu, Gaut, Joseph P., Faugere, Marie-Claude, Malluche, Hartmut H., Hruska, Keith A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628245/
https://ncbi.nlm.nih.gov/pubmed/28843411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.06.016
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