The activin receptor is stimulated in the skeleton, vasculature, heart and kidney during chronic kidney disease.

We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome, using the ActRIIA ligand trap RAP-011 initiated in 75 day old Alport mice. At 200 days of age there was severe CKD and associated Mineral and Bon...

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Pubblicato in:Kidney Int
Autori principali: Williams, Matthew J., Sugatani, Toshifumi, Agapova, Olga A., Fang, Yifu, Gaut, Joseph P., Faugere, Marie-Claude, Malluche, Hartmut H., Hruska, Keith A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628245/
https://ncbi.nlm.nih.gov/pubmed/28843411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.06.016
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