Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

[Image: see text] Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medi...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J., Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O., Henderson, Mark J., Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M., Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O., Shi, Wei Q.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2019
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627486/
https://ncbi.nlm.nih.gov/pubmed/31059257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13506
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