Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

[Image: see text] Ipomoeassin F is a potent natural cytotoxin that inhibits growth of many tumor cell lines with single-digit nanomolar potency. However, its biological and pharmacological properties have remained largely unexplored. Building upon our earlier achievements in total synthesis and medi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Zong, Guanghui, Hu, Zhijian, O’Keefe, Sarah, Tranter, Dale, Iannotti, Michael J., Baron, Ludivine, Hall, Belinda, Corfield, Katherine, Paatero, Anja O., Henderson, Mark J., Roboti, Peristera, Zhou, Jianhong, Sun, Xianwei, Govindarajan, Mugunthan, Rohde, Jason M., Blanchard, Nicolas, Simmonds, Rachel, Inglese, James, Du, Yuchun, Demangel, Caroline, High, Stephen, Paavilainen, Ville O., Shi, Wei Q.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2019
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627486/
https://ncbi.nlm.nih.gov/pubmed/31059257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b13506
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