Enhanced Inhibition of Influenza A Virus Adhesion by Di- and Trivalent Hemagglutinin Inhibitors

[Image: see text] Multivalent carbohydrate-based ligands were synthesized and evaluated as inhibitors of the adhesion protein HA of the influenza A virus (IAV). HA relies on multivalency for strong viral adhesion. While viral adhesion inhibition by large polymeric molecules has proven viable, limite...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Lu, Wenjing, Du, Wenjuan, Somovilla, Victor J., Yu, Guangyun, Haksar, Diksha, de Vries, Erik, Boons, Geert-Jan, de Vries, Robert P., de Haan, Cornelis A. M., Pieters, Roland J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2019
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627469/
https://ncbi.nlm.nih.gov/pubmed/31251606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00303
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