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The macrophage checkpoint CD47 : SIRPα for recognition of ‘self’ cells: from clinical trials of blocking antibodies to mechanobiological fundamentals
Immunotherapies against some solid tumour types have recently shown unprecedented, durable cures in the clinic, and the most successful thus far involves blocking inhibitory receptor ‘checkpoints’ on T cells. A similar approach with macrophages is emerging by blocking the ubiquitously expressed ‘mar...
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| Publicado en: | Philos Trans R Soc Lond B Biol Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Royal Society
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6627025/ https://ncbi.nlm.nih.gov/pubmed/31431181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2018.0217 |
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