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Membrane fluctuations and acidosis regulate cooperative binding of ‘marker of self’ protein CD47 with the macrophage checkpoint receptor SIRPα
Cell-cell interactions that result from membrane proteins binding weakly in trans can cause accumulations in cis that suggest cooperativity and thereby an acute sensitivity to environmental factors. The ubiquitous ‘marker of self’ protein CD47 binds weakly to SIRPα on macrophages, which leads to acc...
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| 出版年: | J Cell Sci |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Company of Biologists Ltd
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6398477/ https://ncbi.nlm.nih.gov/pubmed/29777034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.216770 |
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