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Membrane fluctuations and acidosis regulate cooperative binding of ‘marker of self’ protein CD47 with the macrophage checkpoint receptor SIRPα
Cell-cell interactions that result from membrane proteins binding weakly in trans can cause accumulations in cis that suggest cooperativity and thereby an acute sensitivity to environmental factors. The ubiquitous ‘marker of self’ protein CD47 binds weakly to SIRPα on macrophages, which leads to acc...
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| Publicado no: | J Cell Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6398477/ https://ncbi.nlm.nih.gov/pubmed/29777034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.216770 |
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