Melanoma Progression Inhibits Pluripotency and Differentiation of Melanoma-Derived iPSCs Produces Cells with Neural-like Mixed Dysplastic Phenotype

Melanomas are known to exhibit phenotypic plasticity. However, the role cellular plasticity plays in melanoma tumor progression and drug resistance is not fully understood. Here, we used reprogramming of melanocytes and melanoma cells to induced pluripotent stem cell (iPSCs) to investigate the relat...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Castro-Pérez, Edgardo, Rodríguez, Carlos I., Mikheil, Dareen, Siddique, Shakir, McCarthy, Alexandra, Newton, Michael A., Setaluri, Vijayasaradhi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627006/
https://ncbi.nlm.nih.gov/pubmed/31231022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.05.018
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