Nature’s combinatorial biosynthesis produces vatiamides A-F

Hybrid type I PKS/NRPS biosynthetic pathways typically proceed in a collinear manner wherein one molecular building block is enzymatically incorporated in a sequence that corresponds with gene arrangement. Here, genome mining combined with use of a fluorogenic azide-based click probe led to the disc...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Moss, Nathan A., Seiler, Grant, Leão, Tiago F., Castro-Falcón, Gabriel, Gerwick, Lena, Hughes, Chambers C., Gerwick, William H.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626303/
https://ncbi.nlm.nih.gov/pubmed/31071229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201902571
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