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Ketoreductase domain dysfunction expands chemodiversity: malyngamide biosynthesis in the cyanobacterium Okeania hirsuta

Dozens of type A malyngamides, principally identified by a decorated six-membered cyclohexanone head group and methoxylated lyngbic acid tail, have been isolated over several decades. Their environmental sources include macro-and microbiotic organisms, including sea hares, red alga, and cyanobacteri...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Moss, Nathan A., Leão, Tiago, Rankin, Michael R., McCullough, Tyler M., Qu, Pingping, Korobeynikov, Anton, Smith, Janet L., Gerwick, Lena, Gerwick, William H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470004/
https://ncbi.nlm.nih.gov/pubmed/30444349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00910
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