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Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action

New methods are urgently needed to find novel natural products as structural leads for the development of new drugs against emerging diseases such as cancer and multiresistant bacterial infections. Here we introduce a reactivity-guided drug discovery approach for electrophilic natural products, a th...

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Библиографические подробности
Опубликовано в: :ACS Chem Biol
Главные авторы: Castro-Falcón, Gabriel, Hahn, Dongyup, Reimer, Daniela, Hughes, Chambers C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295175/
https://ncbi.nlm.nih.gov/pubmed/27294329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00924
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