Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Dimethyl fumarate (DMF) is a first-line-treatment for relapsing-remitting multiple sclerosis (RRMS). The redox master regulator Nrf2, essential for redox balance, is a target of DMF, but its precise therapeutic mechanisms of action remain elusive. Here we show impact of DMF on circulating monocytes...

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Publicat a:Nat Commun
Autors principals: Carlström, Karl E., Ewing, Ewoud, Granqvist, Mathias, Gyllenberg, Alexandra, Aeinehband, Shahin, Enoksson, Sara Lind, Checa, Antonio, Badam, Tejaswi V. S., Huang, Jesse, Gomez-Cabrero, David, Gustafsson, Mika, Al Nimer, Faiez, Wheelock, Craig E., Kockum, Ingrid, Olsson, Tomas, Jagodic, Maja, Piehl, Fredrik
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6626021/
https://ncbi.nlm.nih.gov/pubmed/31300673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11139-3
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