Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by genetic and environmental factors. DNA methylation, an epigenetic mechanism that controls genome activity, may provide a link between genetic and environmental risk factors. OBJECTIVE: We so...

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Detalles Bibliográficos
Publicado en:Mult Scler
Main Authors: Ruhrmann, Sabrina, Ewing, Ewoud, Piket, Eliane, Kular, Lara, Cetrulo Lorenzi, Julio Cesar, Fernandes, Sunjay Jude, Morikawa, Hiromasa, Aeinehband, Shahin, Sayols-Baixeras, Sergi, Aslibekyan, Stella, Absher, Devin M, Arnett, Donna K, Tegner, Jesper, Gomez-Cabrero, David, Piehl, Fredrik, Jagodic, Maja
Formato: Artigo
Idioma:Inglês
Publicado: SAGE Publications 2017
Assuntos:
Original Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5794671/
https://ncbi.nlm.nih.gov/pubmed/28766461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1352458517721356
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