MST1R Kinase Accelerates Pancreatic Cancer Progression Via Effects on both Epithelial Cells and Macrophages

The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined the relevance of Mst1r kinase to Kras driven pancreatic carcinogenesis using genetically engineered mouse models. In the setting of mutant...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Babicky, Michele L., Harper, Megan M., Chakedis, Jeffery, Cazes, Alex, Mose, Evangeline S., Jaquish, Dawn V., French, Randall P., Childers, Betzaira, Alakus, Hakan, Schmid, Michael C., Foubert, Phillippe, Miyamoto, Jaclyn, Holman, Patrick J., Walterscheid, Zakkary J., Tang, Chih-Min, Varki, Nissi, Sicklick, Jason K., Messer, Karen, Varner, Judith A., Waltz, Susan E., Lowy, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625868/
https://ncbi.nlm.nih.gov/pubmed/30967626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0811-9
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