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Position of lipidation influences anticancer activity of Smac analogs
A small group of lipid-conjugated Smac mimetics was synthesized to probe the influence of the position of lipidation on overall anti-cancer activity. Specifically, new compounds were modified with lipid(s) in position 3 and C-terminus. Previously described position 2 lipidated analog M11 was also sy...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6625762/ https://ncbi.nlm.nih.gov/pubmed/31047753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.04.041 |
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