Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk

There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix (ECM), including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we found a clinical correlation between the ex...

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Foilsithe in:Cancer Res
Main Authors: Sun, Tao, Patil, Rameshwar, Galstyan, Anna, Klymyshyn, Dmytro, Ding, Hui, Chesnokova, Alexandra, Cavenee, Webster K., Furnari, Frank B., Ljubimov, Vladimir A., Shatalova, Ekaterina S., Wagner, Shawn, Li, Debiao, Mamelak, Adam N., Bannykh, Serguei I., Patil, Chirag G., Rudnick, Jeremy D., Hu, Jethro, Grodzinski, Zachary B., Rekechenetskiy, Arthur, Falahatian, Vida, Lyubimov, Alexander V., Chen, Yongmei L., Leoh, Lai S., Daniels-Wells, Tracy R., Penichet, Manuel L., Holler, Eggehard, Ljubimov, Alexander V., Black, Keith L., Ljubimova, Julia Y.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625517/
https://ncbi.nlm.nih.gov/pubmed/30659021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2725
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