SCDT-39. NANOBIOCONJUGATES CROSSING BBB FOR DELIVERY OF CHECKPOINT INHIBITORS AND ACTIVATION OF LOCAL BRAIN TUMOR IMMUNE SYSTEMS FOR GLIOMA TREATMENT

Glioblastoma multiforme (GBM) still has limited treatment options. We introduce a new generation of nanobioconjugates that deliver anti-CTLA-4 and/or anti-PD-1 antibodies through blood-brain barrier (BBB) and activate local brain tumor immune response directed against GBM. METHODS: Immuno-nanobiocon...

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Опубликовано в: :Neuro Oncol
Главные авторы: Ljubimova, Julia, Ding, Hui, Galstyan, Anna, Chiechi, Antonella, Tao, San, Shatalova, Eketerina, Penichet, Manuel, Ljubimov, Alexander, Holler, Eggehard, Black, Keith
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691930/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1120
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