Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk

There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix (ECM), including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we found a clinical correlation between the ex...

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Pubblicato in:Cancer Res
Autori principali: Sun, Tao, Patil, Rameshwar, Galstyan, Anna, Klymyshyn, Dmytro, Ding, Hui, Chesnokova, Alexandra, Cavenee, Webster K., Furnari, Frank B., Ljubimov, Vladimir A., Shatalova, Ekaterina S., Wagner, Shawn, Li, Debiao, Mamelak, Adam N., Bannykh, Serguei I., Patil, Chirag G., Rudnick, Jeremy D., Hu, Jethro, Grodzinski, Zachary B., Rekechenetskiy, Arthur, Falahatian, Vida, Lyubimov, Alexander V., Chen, Yongmei L., Leoh, Lai S., Daniels-Wells, Tracy R., Penichet, Manuel L., Holler, Eggehard, Ljubimov, Alexander V., Black, Keith L., Ljubimova, Julia Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625517/
https://ncbi.nlm.nih.gov/pubmed/30659021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2725
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