Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk

There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix (ECM), including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we found a clinical correlation between the ex...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Sun, Tao, Patil, Rameshwar, Galstyan, Anna, Klymyshyn, Dmytro, Ding, Hui, Chesnokova, Alexandra, Cavenee, Webster K., Furnari, Frank B., Ljubimov, Vladimir A., Shatalova, Ekaterina S., Wagner, Shawn, Li, Debiao, Mamelak, Adam N., Bannykh, Serguei I., Patil, Chirag G., Rudnick, Jeremy D., Hu, Jethro, Grodzinski, Zachary B., Rekechenetskiy, Arthur, Falahatian, Vida, Lyubimov, Alexander V., Chen, Yongmei L., Leoh, Lai S., Daniels-Wells, Tracy R., Penichet, Manuel L., Holler, Eggehard, Ljubimov, Alexander V., Black, Keith L., Ljubimova, Julia Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625517/
https://ncbi.nlm.nih.gov/pubmed/30659021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-2725
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