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Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK inhibitor ruxolitinib dampens T-cell activation...
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| 出版年: | Blood |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6624972/ https://ncbi.nlm.nih.gov/pubmed/31015190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000761 |
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