Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is an often-fatal disorder characterized by the overactivation of T cells and macrophages that excessively produce proinflammatory cytokines, including interferon-γ (IFN-γ). Previously, we reported that the JAK inhibitor ruxolitinib dampens T-cell activation...

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Foilsithe in:Blood
Main Authors: Albeituni, Sabrin, Verbist, Katherine C., Tedrick, Paige E., Tillman, Heather, Picarsic, Jennifer, Bassett, Rachel, Nichols, Kim E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2019
Ábhair:
Immunobiology and Immunotherapy
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624972/
https://ncbi.nlm.nih.gov/pubmed/31015190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000761
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